ANIMAL MODELS

IN VIVO PHARMACOLOGY CAPABILITIES

1 - IN VIVO DRUG EFFICACY EVALUATION

Types of Animal models (mouse and minipig)

— Subcutaneous xenograft models

— Orthotopic tumor models

— Metastatic tumor models

— PDX – patient derived tumor models

— GEM mice models

— Minipig Skin disease models (syngeneic melanoma, etc.)

2 - BIOMARKER DETECTION AND ANALYSIS

3 - TOXICITY STUDIES

— mouse

— minipig

4 - PHARMACOKINETIC STUDIES

5. EVALUATION

A) Tumor Growth

-          Growth Curves

-          Tumor weight

-          Necrosis

-          Apoptosis

-          Angiogenesis

-          Immune response

-          Proliferation

-          Methastasis

-          In vivo target expression

-          Ex vivo cell function

B) Methods

- Caliper based phisical tumor measurement, tumor weight, body weight, organ weight,

- organ and tumor sections, gross pathology and hystopathology, immune staining, IHC, Tunnel Assay etc.

- In vivo Bioluminescence Imaging (Luciferase-based system)

 

 

Authority License Number: III/10-KÁFH/2016, DE MAB